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KMID : 0377519970220030137
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Chung-Ang Journal of Medicine
1997 Volume.22 No. 3 p.137 ~ p.144
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Quantitation of plasma D-dimer by ELISA in patients with diabetes mellitus type Ⅱ
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Cha Young-Joo
Chang Eun-Ah
Chae Seok-Lae
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Abstract
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Patients with Type Ⅱ (non-insulin dependent) diabetes mellitus (NIDDM) are at increased risk of thrombosis and the premature development of atherosclerosis. Hypercoagulability may play a critical role in the pathogenesis of atherogenesis and thrombosis in diabetic patients. The purpose of this study was to clarify whether hypercoagulability exists in patients with NIDDM and microvascular complications. Plasma D-dimer levels which may reflect the increased fibrinolytic activity as a result of hypercoagulable state were measured by ELISA in 30 healthy controls, 20 NIDDM patients without any complications and 23 NIDDM patients with microvascular complications. D-dimer level was significantly higher(228.5 ± 134.7 ng/ml,mean ± SD) in 43 NIDDM patients than that of healthy controls (120.2 ± 53.6 ng/ml). However, there was no significant difference of plasma D-dimer levels between NIDDM groups with or without complications. The frequency of elevated D-dimer levels (＞ 227.4 ng/mL) was higher in NIDDM patients with complications(47.8%) than in the patients without complications(20.0%). It is suggested that the hypercoagulable state existed in NIDDM patients, and other complex factors as well as hypercoagulability may have influence on the development of microvascular complications in NIDDM.
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KEYWORD
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D-dimer, NIDDM
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